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Prof. Wu Haoxing’s team Publishes design strategy on Angewandte Chemie

Recently, Prof. Wu Haoxing’s research group with the Clinical MR Research Center of West China Hospital published a research article entitled A General Strategy to Design Highly Fluorogenic Far-red and Near-infracted Tetrazine Bioorthogonal Probes in Angewandte Chemie (IF: 12.96), a well-known journal in the field of chemistry, reporting a new type of fluorogenic probe that can be used for imaging of living cells and body.

Fluorescent probes can not only label biological macromolecules at the subcellular level, reveal their role in the molecular networks, and explore the molecular mechanism of related pathological processes. At the same time, it can be used as a signal means to label a plurality of cells and tissues, thus realizing the optical tracing and surgical navigation of specific targets such as tumor metastatic lesions and neural structures. In this study, a new opening method of fluorescent probe was designed through a new chemical biology technology—bioorthogonal chemistry. The research team named this new fluorogenic skeleton as Huaxi-Fluors.

Thanks to the effectiveness of the new technology of bioorthogonal chemistry, the world’s first clinical experiment based on bioorthogonal technology has attracted extensive attention across the world recently. It is believed that the reported Huaxi-Fluors probe will also have good application prospects in the biomedical fields such as fluorogenic live-cell imaging and surgical navigation.

Linkage to the original article: 1002/anie.202011544